Lesion complexity determines arterial drug distribution after local drug delivery
نویسندگان
چکیده
منابع مشابه
Local Drug Delivery
Periodontal diseases are considered infection of the periodontium, because there is bacterial etiology, an immune response, and tissue destruction. Putative pathogens associated with periodontal diseases are susceptible to a variety of antiseptics and antibiotics. Methods employed to convey antimicrobial agents into periodontal pockets have included rinsing, irrigation, systemic administration,...
متن کاملDrug clearance and arterial uptake after local perivascular delivery to the rat carotid artery.
OBJECTIVES We attempted to characterize how drug released into the perivascular space enters the arterial wall and how it is cleared from the local environment. BACKGROUND Drug released into the perivascular space can enter the artery either from the adventitial aspect or from the lumen after absorption by the extraarterial capillaries and mixing within the systemic circulation. Some investig...
متن کاملLocal drug delivery in periodontology
Periodontitis describes a group of related inflammatory disease resulting in destruction of the tissues that support the tooth. It results from extension of the inflammatory process initiated in the gingiva to the supporting periodontal tissues. Clinical features of periodontitis include bleeding, pus discharge, halitosis, tooth mobility, functional impairment and ultimately tooth loss. Scaling...
متن کاملModelling intravascular delivery from drug-eluting stents with biodurable coating: investigation of anisotropic vascular drug diffusivity and arterial drug distribution.
In-stent restenosis occurs in coronary arteries after implantation of drug-eluting stents with non-uniform restenosis thickness distribution in the artery cross section. Knowledge of the spatio-temporal drug uptake in the arterial wall is useful for investigating restenosis growth but may often be very expensive/difficult to acquire experimentally. In this study, local delivery of a hydrophobic...
متن کاملThrombosis modulates arterial drug distribution for drug-eluting stents.
BACKGROUND Drug-eluting stents deliver potent compounds directly to arterial segments but can become clot laden when deployed. The question arises as to whether thrombi affect drug elution and arterial uptake. METHODS AND RESULTS Paclitaxel transport and retention were assessed in clots of different blood components. Diffusivity, affected by clot organization, is fastest in fibrin (approximat...
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ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2010
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2009.11.007